Recombinant Human FLT3 Ligand Protein
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Recombinant Human FLT3 Ligand Protein
- Stock: In Stock
- Model: GMP-TL505
$157.00
Available Options
FLT3 ligand is a growth factor that regulates the proliferation of early hematopoietic cells. FLT 3-ligand binds to cells expressing tyrosine kinase receptor FLT3. The FLT3 ligand itself does not stimulate the proliferation of early hematopoietic cells, but rather synergistically induces growth and differentiation with other CSFs and interleukins. Unlike SCF, FLT3 ligand has no effect on mast cell. Multiple subtypes of FLT3-ligands have been identified.The main bioactive form is anchored on the cell surface as the extracellular domain of transmembrane protein (209 a.). The membrane binding isomers can be cleaved by proteins to form biologically active soluble isomers.
Cytokines | |
Expression Host | HEK293 cells |
Synonym | FLT3LG,FL,FLT3L,Flt3 ligand |
Protein Sequence | A DNA sequence encoding the human FLT3 Ligand(NP_001450.2)was expressed with a His tag at the C-terminus. |
Molecular Mass | The recombinant human FLT3 Ligand protein contains 161 amino acids with a predicted molecular weight of 18.4 kD. |
QC Testing Purity | > 90 % as determined by SDS-PAGE. |
Endotoxin | < 0.1EU per 1μg of the protein as determined by the LAL method. |
Activity | Measured by the dose-dependent stimulation of the proliferation of OCI-AML5 cells.The specific activity is ≥5.0×10⁵IU/mg. |
Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization. |
Stability | Lyophilized preparation can be stored at -20℃. 6 months at -20℃ under sterile conditions after reconstitution. 12 months at -80℃ under sterile conditions after reconstitution. |
Storage | Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL. Avoid repeated freeze-thaw cycles. |
Thumb | File information |
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GMP-TL505_Product Sheet.pdf File Size84.27KB Downloaded: 65 |
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GMP-TL505_SDS.pdf File Size153.5KB Downloaded: 67 |