Recombinant Human IFN-γ Protein

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Model: GMP-TL105

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Tags: Immune Cell Culture , Macrophages

IFN-γ is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. IFN-γ exerts a wide range of immunoregulatory activities and plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up-regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-γ has a strong inhibitory effect on the activation, proliferation and secretion of extracellular matrix of hepatic stellate cells (HSC), and it can inhibit collagen synthesis and promote collagen degradation.

Cytokines
Expression Host	HEK293 cells
Synonym	Interferon-gamma, Interferon-γ
Protein Sequence	Accession # AAH70256 Q24-Q166
Molecular Mass	Predicts a molecular mass of 17.6 kDa
QC Testing Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 0.1EU per 1 μg of the protein by the LAL method.
Activity	Measured in anti-viral assays protecting human amniotic cells (WISH) from the destructive effects of vesicular stomatitis virus (VSV). The ED₅₀ for this effect is ≤50 ng/mL.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.
Stability	24 months at -20℃ in lyophilized state. 6 months at -20℃ under sterile conditions after reconstitution. 12 months at -80℃ under sterile conditions after reconstitution.
Storage	Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL. Avoid repeated freeze-thaw cycles.