Recombinant Human IFN-γ Protein
![Recombinant Human IFN-γ Protein Recombinant Human IFN-γ Protein](https://www.tlbiotechnology.com/image/cache/catalog/Cytokines-550x550w.png)
Recombinant Human IFN-γ Protein
- Stock: In Stock
- Model: GMP-TL105
$226.00
Available Options
IFN-γ is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. IFN-γ exerts a wide range of immunoregulatory activities and plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up-regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-γ has a strong inhibitory effect on the activation, proliferation and secretion of extracellular matrix of hepatic stellate cells (HSC), and it can inhibit collagen synthesis and promote collagen degradation.
Cytokines | |
Expression Host | HEK293 cells |
Synonym | Interferon-gamma, Interferon-γ |
Protein Sequence | Accession # AAH70256 Q24-Q166 |
Molecular Mass | Predicts a molecular mass of 17.6 kDa |
QC Testing Purity | > 90 % as determined by SDS-PAGE |
Endotoxin | < 0.1EU per 1 μg of the protein by the LAL method. |
Activity | Measured in anti-viral assays protecting human amniotic cells (WISH) from the destructive effects of vesicular stomatitis virus (VSV). The ED₅₀ for this effect is ≤50 ng/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization. |
Stability | 24 months at -20℃ in lyophilized state. 6 months at -20℃ under sterile conditions after reconstitution. 12 months at -80℃ under sterile conditions after reconstitution. |
Storage | Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL. Avoid repeated freeze-thaw cycles. |
Thumb | File information |
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GMP-TL105_SDS.pdf File Size171.27KB Downloaded: 56 |
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GMP-TL105_Product Sheet.pdf File Size135.67KB Downloaded: 35 |