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Recombinant Human IL-3 Protein

Recombinant Human IL-3 Protein
Recombinant Human IL-3 Protein
  • Stock: In Stock
  • Model: GMP-TL511
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Tags: iPSC related Products , Hematopoietic Stem Cell related Products
Activated T cells generally cannot survive for a long time in vitro culture, and the addition of IL-2 can promote their long-term and sustained proliferation. The surface of stationary T cells does not express IL-2R and does not respond to IL-2; T cells activated by mitogen or other stimuli can express IL-2R and become target cells of IL-2; IL-2 can also induce increased IL-2R expression in target cells. The expression of IL-2R on T cells is transient, generally reaching its peak 2-3 days after activation and disappearing around 6-10 days. With the disappearance of IL-2R, T cells lose their ability to respond to IL-2. Therefore, in order to maintain the long-term growth of normal T cells in vitro, it is necessary to constantly stimulate T cells with mitogen or other stimulators to maintain the expression of IL-2R. NK cells are the only lymphoid cells that normally express IL-2R, and therefore always maintain reactivity to IL-2. However, only IL-2R is expressed on stationary NK cells β Chain and γ Chains have a low affinity for IL-2 and can only react with high concentrations of IL-2. Once NK cells are activated, they express IL-2R α Chain, becoming a high affinity receptor.


Cytokines
Expression Host A DNA sequence encoding the human IL-3 (GenBank: AAA59146.1) was expressed with a His-tag at the C-terminus.
Synonym StabilityStabilityStabilityStability
Protein Sequence Protein SequenceProtein Sequence
Molecular Mass Molecular MassMolecular Mass
QC Testing Purity QC Testing PurityQC Testing Purity
Endotoxin MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor
Activity HEK293 cells
Formulation The recombinant human IL-3 protein consists of 139 amino acids and predicts a molecular mass of 15.9 kD.
Stability StabilityStabilityStabilityStability
Storage StorageStorageStorage
Thumb File information
GMP-TL511_Product Sheet.pdf 80.66KB 83
GMP-TL511_SDS.pdf 161.55KB 96

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